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Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues

Clinical features of idiosyncratic drug induced liver injury (DILI) are well described in cases that have been assessed for causality using the Roussel Uclaf Causality Assessment Method (RUCAM), but our understanding of the mechanistic steps leading to injury is fragmentary. The difficulties describ...

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Bibliografische gegevens
Gepubliceerd in:Ann Transl Med
Hoofdauteurs: Teschke, Rolf, Uetrecht, Jack
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AME Publishing Company 2021
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106057/
https://ncbi.nlm.nih.gov/pubmed/33987428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm-2020-ubih-05
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