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Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461
CX-5461 is a G-quadruplex (G4) ligand currently in trials with initial indications of clinical activity in cancers with defects in homologous recombination repair. To identify more genetic defects that could sensitize tumors to CX-5461, we tested synthetic lethality for 480 DNA repair and genome mai...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8105411/ https://ncbi.nlm.nih.gov/pubmed/33963218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88988-w |
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