A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia.

Bacterial endotoxin (lipopolysaccharide [LPS]) causes severe damage to the host organism as a result of excessive release of inflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha), from mononuclear phagocytes during gram-negative bacterial infection. We ev...

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Bibliographic Details
Main Authors: Sato, K, Yoo, Y C, Fukushima, A, Saiki, I, Takahashi, T A, Fujihara, M, Tono-Oka, S, Azuma, I
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC173388/
https://ncbi.nlm.nih.gov/pubmed/7622206
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