A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia.

Bacterial endotoxin (lipopolysaccharide [LPS]) causes severe damage to the host organism as a result of excessive release of inflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha), from mononuclear phagocytes during gram-negative bacterial infection. We ev...

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Pubblicato in:	Infect Immun
Autori principali:	Sato, K, Yoo, Y C, Fukushima, A, Saiki, I, Takahashi, T A, Fujihara, M, Tono-Oka, S, Azuma, I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173388/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7622206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.8.2859-2866.1995
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