TSP-1 deficiency protects ApoE(−/−) mice against leptin-induced atherosclerosis

OBJECTIVE –: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on thrombospondin-1 (TSP-1) expression, a proatherogenic matricellular protein implicated in atherogenesis. However, a causal role of T...

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Xehetasun bibliografikoak
Argitaratua izan da:Arterioscler Thromb Vasc Biol
Egile Nagusiak: Ganguly, Rituparna, Khanal, Saugat, Mathias, Amy, Gupta, Shreya, Lallo, Jason, Sahu, Soumyadip, Ohanyan, Vahagn, Patel, Aakaash, Storm, Kyle, Datta, Sujay, Raman, Priya
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8105272/
https://ncbi.nlm.nih.gov/pubmed/33327743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314962
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