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TSP-1 deficiency protects ApoE(−/−) mice against leptin-induced atherosclerosis
OBJECTIVE –: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on thrombospondin-1 (TSP-1) expression, a proatherogenic matricellular protein implicated in atherogenesis. However, a causal role of T...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8105272/ https://ncbi.nlm.nih.gov/pubmed/33327743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314962 |
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