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An Overview of PARP Inhibitors for the Treatment of Breast Cancer
Loss-of-function mutations in BRCA1 and BRCA2 are detected in at least 5% of unselected patients with breast cancer (BC). These BC susceptibility genes encode proteins critical for DNA homologous recombination repair (HRR). This review provides an update on oral poly(ADP-ribose) polymerase (PARP) in...
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| Publié dans: | Target Oncol |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer International Publishing
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8105250/ https://ncbi.nlm.nih.gov/pubmed/33710534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-021-00796-4 |
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