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Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum

Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced in Leishmania by the bifunctional dihydrofolate reductase thymidylate synthase (DHFR-TS) and by pteridine reductase (PTR1). To further our un...

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Dades bibliogràfiques
Publicat a:PLoS Negl Trop Dis
Autors principals: Bhattacharya, Arijit, Leprohon, Philippe, Ouellette, Marc
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8104401/
https://ncbi.nlm.nih.gov/pubmed/33905412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0009377
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