Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi

Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate syn...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Teixeira, Bárbara Velame Ferreira, Teles, André Lacerda Braga, da Silva, Suellen Gonçalves, Brito, Camila Carane Bitencourt, de Freitas, Humberto Fonseca, Pires, Acássia Benjamim Leal, Froes, Thamires Quadros, Castilho, Marcelo Santos
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713189/
https://ncbi.nlm.nih.gov/pubmed/31409157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1651311
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