Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi

Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate syn...

詳細記述

保存先:
書誌詳細
出版年:J Enzyme Inhib Med Chem
主要な著者: Teixeira, Bárbara Velame Ferreira, Teles, André Lacerda Braga, da Silva, Suellen Gonçalves, Brito, Camila Carane Bitencourt, de Freitas, Humberto Fonseca, Pires, Acássia Benjamim Leal, Froes, Thamires Quadros, Castilho, Marcelo Santos
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2019
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713189/
https://ncbi.nlm.nih.gov/pubmed/31409157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1651311
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