ロード中...
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
Activation of the RIG-I-like receptors, RIG-I and MDA5, establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15 whose mechanistic roles in innate immunity still remain enigmatic. Here we report that ISG15 conjugation is essential for antiviral IF...
保存先:
| 出版年: | Nat Microbiol |
|---|---|
| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
|
| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8103894/ https://ncbi.nlm.nih.gov/pubmed/33727702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-021-00884-1 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|