ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

Activation of the RIG-I-like receptors, RIG-I and MDA5, establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15 whose mechanistic roles in innate immunity still remain enigmatic. Here we report that ISG15 conjugation is essential for antiviral IF...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Microbiol
Main Authors: Liu, GuanQun, Lee, Jung-Hyun, Parker, Zachary M., Acharya, Dhiraj, Chiang, Jessica J., van Gent, Michiel, Riedl, William, Davis-Gardner, Meredith E., Wies, Effi, Chiang, Cindy, Gack, Michaela U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103894/
https://ncbi.nlm.nih.gov/pubmed/33727702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-021-00884-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados