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Zika virus NS3 mimics a cellular 14-3-3-binding motif to antagonize RIG-I- and MDA5-mediated innate immunity
14–3-3 protein family members facilitate the translocation of RIG-I-like receptors (RLRs) to organelles that mediate downstream RLR signaling, leading to interferon production. 14–3-3ε promotes the cytosolic-to-mitochondrial translocation of RIG-I, while 14–3-3η facilitates MDA5 translocation to mit...
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| Publicado no: | Cell Host Microbe |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6922055/ https://ncbi.nlm.nih.gov/pubmed/31600501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.09.012 |
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