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Lipid Nanoparticle-Mediated Lymphatic Delivery of Immunostimulatory Nucleic Acids

Lymphatic delivery of a vaccine can be achieved using a dendritic cell (DC)-targeted delivery system that can cause DC to migrate to lymph nodes upon activation by an adjuvant. Here, we designed a mannose-modified cationic lipid nanoparticle (M-NP) to deliver the nucleic acid adjuvant, polyinosinic:...

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Bibliografiske detaljer
Udgivet i:Pharmaceutics
Main Authors: Kim, Dongyoon, Wu, Yina, Shim, Gayong, Oh, Yu-Kyoung
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103501/
https://ncbi.nlm.nih.gov/pubmed/33916667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13040490
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