Rqc1 and other yeast proteins containing highly positively charged sequences are not targets of the RQC complex

Previous work has suggested that highly positively charged protein segments coded by rare codons or poly (A) stretches induce ribosome stalling and translational arrest through electrostatic interactions with the negatively charged ribosome exit tunnel, leading to inefficient elongation. This arrest...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Barros, Géssica C., Requião, Rodrigo D., Carneiro, Rodolfo L., Masuda, Claudio A., Moreira, Mariana H., Rossetto, Silvana, Domitrovic, Tatiana, Palhano, Fernando L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102910/
https://ncbi.nlm.nih.gov/pubmed/33774050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100586
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