Rqc1 and other yeast proteins containing highly positively charged sequences are not targets of the RQC complex

Previous work has suggested that highly positively charged protein segments coded by rare codons or poly (A) stretches induce ribosome stalling and translational arrest through electrostatic interactions with the negatively charged ribosome exit tunnel, leading to inefficient elongation. This arrest...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Barros, Géssica C., Requião, Rodrigo D., Carneiro, Rodolfo L., Masuda, Claudio A., Moreira, Mariana H., Rossetto, Silvana, Domitrovic, Tatiana, Palhano, Fernando L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102910/
https://ncbi.nlm.nih.gov/pubmed/33774050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100586
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