Influence of low tumor content on tumor mutational burden estimation by whole‐exome sequencing and targeted panel sequencing

BACKGROUND: Tumor mutational burden (TMB) is a promising biomarker for stratifying patient subpopulation who would benefit from immune checkpoint blockade (ICB) therapies. Although great efforts have been made for standardizing TMB measurement, mutation calling and TMB quantification can be challeng...

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Gepubliceerd in:Clin Transl Med
Hoofdauteurs: Zhang, Wenxin, Wang, Ruixia, Fang, Huan, Ma, Xiangyuan, Li, Dan, Liu, Tao, Chen, Zhenxi, Wang, Ke, Hao, Shiguang, Yu, Zicheng, Chang, Zhili, Na, Chenglong, Wang, Yin, Bai, Jian, Zhang, Yanyan, Chen, Fang, Li, Miao, Chen, Chao, Wei, Liangshen, Li, Jinghua, Chang, Xiaoyan, Qu, Shoufang, Yang, Ling, Huang, Jie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102856/
https://ncbi.nlm.nih.gov/pubmed/34047470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.415
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