Influence of low tumor content on tumor mutational burden estimation by whole‐exome sequencing and targeted panel sequencing

BACKGROUND: Tumor mutational burden (TMB) is a promising biomarker for stratifying patient subpopulation who would benefit from immune checkpoint blockade (ICB) therapies. Although great efforts have been made for standardizing TMB measurement, mutation calling and TMB quantification can be challeng...

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Pubblicato in:Clin Transl Med
Autori principali: Zhang, Wenxin, Wang, Ruixia, Fang, Huan, Ma, Xiangyuan, Li, Dan, Liu, Tao, Chen, Zhenxi, Wang, Ke, Hao, Shiguang, Yu, Zicheng, Chang, Zhili, Na, Chenglong, Wang, Yin, Bai, Jian, Zhang, Yanyan, Chen, Fang, Li, Miao, Chen, Chao, Wei, Liangshen, Li, Jinghua, Chang, Xiaoyan, Qu, Shoufang, Yang, Ling, Huang, Jie
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102856/
https://ncbi.nlm.nih.gov/pubmed/34047470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.415
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