Influence of low tumor content on tumor mutational burden estimation by whole‐exome sequencing and targeted panel sequencing

BACKGROUND: Tumor mutational burden (TMB) is a promising biomarker for stratifying patient subpopulation who would benefit from immune checkpoint blockade (ICB) therapies. Although great efforts have been made for standardizing TMB measurement, mutation calling and TMB quantification can be challeng...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Clin Transl Med
Main Authors: Zhang, Wenxin, Wang, Ruixia, Fang, Huan, Ma, Xiangyuan, Li, Dan, Liu, Tao, Chen, Zhenxi, Wang, Ke, Hao, Shiguang, Yu, Zicheng, Chang, Zhili, Na, Chenglong, Wang, Yin, Bai, Jian, Zhang, Yanyan, Chen, Fang, Li, Miao, Chen, Chao, Wei, Liangshen, Li, Jinghua, Chang, Xiaoyan, Qu, Shoufang, Yang, Ling, Huang, Jie
פורמט: Artigo
שפה:Inglês
יצא לאור: John Wiley and Sons Inc. 2021
נושאים:
Research Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102856/
https://ncbi.nlm.nih.gov/pubmed/34047470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.415
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