Endothelial p300 promotes portal hypertension and hepatic fibrosis through CCL2-mediated angiocrine signaling

BACKGROUND & AIMS: During liver fibrosis, liver sinusoidal endothelial cells (LSECs) release angiocrine signals to recruit inflammatory cells into the liver. P300, a master regulator of gene transcription, is associated with pathological inflammatory response. Therefore, we examined how endothel...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Gao, Jinhang, Wei, Bo, Liu, Mengfei, Hirsova, Petra, Sehrawat, Tejasav S., Cao, Sheng, Hu, Xiao, Xue, Fei, Yaqoob, Usman, Kang, Ningling, Cui, Huarui, Pomerantz, William C. K., Kostallari, Enis, Shah, Vijay H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102654/
https://ncbi.nlm.nih.gov/pubmed/33159815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31617
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