Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

BACKGROUND & AIMS: Mechanical forces contribute to portal hypertension (PHTN) and fibrogenesis. We investigated the mechanisms by which forces are transduced by liver sinusoidal endothelial cells (LSECs) into pressure and matrix changes. METHODS: We isolated primary LSECs from mice and induced m...

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Publié dans:Gastroenterology
Auteurs principaux: Hilscher, Moira B., Sehrawat, Tejasav, Arab Verdugo, Juan Pablo, Zeng, Zhutian, Gao, Jinhang, Liu, Mengfei, Kostallari, Enis, Gao, Yandong, Simonetto, Douglas A., Yaqoob, Usman, Cao, Sheng, Revzin, Alexander, Beyder, Arthur, Wang, Rong, Kamath, Patrick S., Kubes, Paul, Shah, Vijay H.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581607/
https://ncbi.nlm.nih.gov/pubmed/30872106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.03.013
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