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Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma

A key hallmark of cancer, altered metabolism, is central to cancer pathogenesis and therapy resistance. Robust glutamine metabolism is among cellular processes regulating tumor progression and responsiveness to therapy in a number of cancers, including melanoma and breast cancer. Among mechanisms un...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Feng, Yongmei, Pathria, Gaurav, Heynen-Genel, Susanne, Jackson, Michael, James, Brian, Yin, Jun, Scott, David A., Ronai, Ze’ev A.
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102370/
https://ncbi.nlm.nih.gov/pubmed/33632871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0354
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