SWI/SNF complex mutations promote thyroid tumor progression and insensitivity to redifferentiation therapies.

Mutations of subunits of the SWI/SNF chromatin remodeling complexes occur commonly in cancers of different lineages, including advanced thyroid cancers. Here we show that thyroid-specific loss of Arid1a, Arid2 or Smarcb1 in mouse Braf(V600E)-mutant tumors promotes disease progression and decreased s...

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Publicat a:Cancer Discov
Autors principals: Saqcena, Mahesh, Leandro-Garcia, Luis Javier, Maag, Jesper L. V., Tchekmedyian, Vatche, Krishnamoorthy, Gnana P., Tamarapu, Prasanna P., Tiedje, Vera, Reuter, Vincent, Knauf, Jeffrey A., de Stanchina, Elisa, Xu, Bin, Liao, Xiao-Hui, Refetoff, Samuel, Ghossein, Ronald, Chi, Ping, Ho, Alan L., Koche, Richard P., Fagin, James A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102308/
https://ncbi.nlm.nih.gov/pubmed/33318036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0735
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