Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia

Children of Hispanic/Latino ancestry have increased incidence of high-risk B-cell acute lymphoblastic leukemia (HR B-ALL) with poor prognosis. This leukemia is characterized by a single-copy deletion of the IKZF1 (IKAROS) tumor suppressor and increased activation of the PI3K/AKT/mTOR pathway. This i...

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Publicado no:Leukemia
Main Authors: Ge, Zheng, Song, Chunhua, Ding, Yali, Tan, Bi-Hua, Desai, Dhimant, Sharma, Arati, Gowda, Raghavendra, Yue, Feng, Huang, Suming, Spiegelman, Vladimir, Payne, Jonathon L., Reeves, Mark E., Iyer, Soumya, Dhanyamraju, Pavan Kumar, Imamura, Yuka, Bogush, Daniel, Bamme, Yevgeniya, Yang, Yiping, Soliman, Mario, Kane, Shriya, Dovat, Elanora, Schramm, Joseph, Hu, Tommy, McGrath, Mary, Chroneos, Zissis C., Payne, Kimberly J., Gowda, Chandrika, Dovat, Sinisa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102195/
https://ncbi.nlm.nih.gov/pubmed/33531656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-021-01132-5
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