Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia

Children of Hispanic/Latino ancestry have increased incidence of high-risk B-cell acute lymphoblastic leukemia (HR B-ALL) with poor prognosis. This leukemia is characterized by a single-copy deletion of the IKZF1 (IKAROS) tumor suppressor and increased activation of the PI3K/AKT/mTOR pathway. This i...

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Detaylı Bibliyografya
Yayımlandı:Leukemia
Asıl Yazarlar: Ge, Zheng, Song, Chunhua, Ding, Yali, Tan, Bi-Hua, Desai, Dhimant, Sharma, Arati, Gowda, Raghavendra, Yue, Feng, Huang, Suming, Spiegelman, Vladimir, Payne, Jonathon L., Reeves, Mark E., Iyer, Soumya, Dhanyamraju, Pavan Kumar, Imamura, Yuka, Bogush, Daniel, Bamme, Yevgeniya, Yang, Yiping, Soliman, Mario, Kane, Shriya, Dovat, Elanora, Schramm, Joseph, Hu, Tommy, McGrath, Mary, Chroneos, Zissis C., Payne, Kimberly J., Gowda, Chandrika, Dovat, Sinisa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102195/
https://ncbi.nlm.nih.gov/pubmed/33531656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-021-01132-5
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