Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas

BACKGROUND & AIMS: Hepatoblastoma (HB), the most common pediatric liver cancer, often bears β-catenin mutations and deregulates the Hippo tumor suppressor pathway. Murine HBs can be generated by co-expressing β-catenin mutants and the constitutively active Hippo effector YAP(S127A). Some HBs and...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Gastroenterol Hepatol
Autori principali: Wang, Huabo, Lu, Jie, Mandel, Jordan A., Zhang, Weiqi, Schwalbe, Marie, Gorka, Joanna, Liu, Ying, Marburger, Brady, Wang, Jinglin, Ranganathan, Sarangarajan, Prochownik, Edward V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102178/
https://ncbi.nlm.nih.gov/pubmed/33618031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2021.02.004
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