Origin and evolution of the zinc finger antiviral protein

The human zinc finger antiviral protein (ZAP) recognizes RNA by binding to CpG dinucleotides. Mammalian transcriptomes are CpG-poor, and ZAP may have evolved to exploit this feature to specifically target non-self viral RNA. Phylogenetic analyses reveal that ZAP and its paralogue PARP12 share an anc...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Gonçalves-Carneiro, Daniel, Takata, Matthew A., Ong, Heley, Shilton, Amanda, Bieniasz, Paul D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102003/
https://ncbi.nlm.nih.gov/pubmed/33901262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009545
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