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Origins and evolution of tetherin, an orphan antiviral gene

Tetherin encodes an interferon-inducible antiviral protein that traps a broad spectrum of enveloped viruses at infected cell surfaces. Despite the absence of any clearly related gene or activity, we describe possible scenarios by which tetherin arose that exemplify how protein modularity, evolvabili...

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Bibliografiske detaljer
Udgivet i:Cell Host Microbe
Main Authors: Blanco-Melo, Daniel, Venkatesh, Siddarth, Bieniasz, Paul D.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4989275/
https://ncbi.nlm.nih.gov/pubmed/27427209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.06.007
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