Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells

The molecular properties of CD8(+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8(+) T cells, obtained using a modified Antigen-Reactive T cell Enrichment (ARTE) assay, from 39 COVID-19 patients and...

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Sparad:
Bibliografiska uppgifter
I publikationen:Sci Immunol
Huvudupphovsmän: Kusnadi, Anthony, Ramírez-Suástegui, Ciro, Fajardo, Vicente, Chee, Serena J, Meckiff, Benjamin J, Simon, Hayley, Pelosi, Emanuela, Seumois, Grégory, Ay, Ferhat, Vijayanand, Pandurangan, Ottensmeier, Christian H
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2021
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101257/
https://ncbi.nlm.nih.gov/pubmed/33478949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abe4782
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