Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8(+) T cells

The molecular properties of CD8(+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8(+) T cells from 39 COVID-19 patients and 10 healthy subjects. COVID-19 patients segregated into two groups based on...

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Bibliografiska uppgifter
I publikationen:bioRxiv
Huvudupphovsmän: Kusnadi, Anthony, Ramírez-Suástegui, Ciro, Fajardo, Vicente, Chee, Serena J, Meckiff, Benjamin J, Simon, Hayley, Pelosi, Emanuela, Seumois, Grégory, Ay, Ferhat, Vijayanand, Pandurangan, Ottensmeier, Christian H
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359524/
https://ncbi.nlm.nih.gov/pubmed/32676602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.09.194027
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