CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry

Genetic differences in cytochrome P450 (CYP)-mediated metabolism have been known for several decades. The clinically most important polymorphic CYP enzyme is CYP2D6, which plays a key role in the metabolism of many antidepressants and antipsychotics, along with a range of non-psychiatric medications...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Molden, Espen, Jukić, Marin M.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100508/
https://ncbi.nlm.nih.gov/pubmed/33967790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.650750
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