Significantly lower CYP2D6 metabolism measured as the O/N‐desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients

AIMS: CYP2D6*9, CYP2D6*10 and CYP2D6*41 are the most frequent reduced‐function CYP2D6 alleles in Caucasians. Despite lacking in vivo evidence, they are collectively classified with an enzyme activity score of 0.5. Thus, the aim of this study was to compare the functional impact of CYP2D6*9, CYP2D6*1...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Haslemo, Tore, Eliasson, Erik, Jukić, Marin M., Ingelman‐Sundberg, Magnus, Molden, Espen
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303206/
https://ncbi.nlm.nih.gov/pubmed/30312494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13788
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