Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the defining global health emergency of this century. GC-376 is a M(pro) inhibitor with antiviral activity against SARS-CoV-2 in vitro. Using the K18-hACE2 mouse model, the in vivo antiviral efficacy...

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Pubblicato in:Sci Rep
Autori principali: Cáceres, C. Joaquín, Cardenas-Garcia, Stivalis, Carnaccini, Silvia, Seibert, Brittany, Rajao, Daniela S., Wang, Jun, Perez, Daniel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100161/
https://ncbi.nlm.nih.gov/pubmed/33953295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89013-w
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