Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the defining global health emergency of this century. GC-376 is a M (pro) inhibitor with antiviral activity against SARS-CoV-2 in vitro . Using the K18-hACE2 mouse model, the in vivo antiviral efficac...

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Bibliographic Details
Published in:bioRxiv
Main Authors: Joaquín Cáceres, C., Cardenas-Garcia, Stivalis, Carnaccini, Silvia, Seibert, Brittany, Rajao, Daniela S., Wang, Jun, Perez, Daniel R.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852269/
https://ncbi.nlm.nih.gov/pubmed/33532776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.27.428428
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