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Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
Endogenous cardiac pacemaker function regulates the rate and rhythm of cardiac contraction. The mutation p.Lys23Glu in the cohesin protein Shugoshin-1 causes severe heart arrhythmias due to sinoatrial node dysfunction and a debilitating gastrointestinal motility disorder, collectively termed the Chr...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8100125/ https://ncbi.nlm.nih.gov/pubmed/33953173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22737-5 |
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