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Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells

Tobacco smoking is the largest risk factor for developing chronic obstructive pulmonary disease (COPD), and is associated with hyperresponsiveness of airway smooth muscle (ASM). Chronic exposure to cigarette smoke (CS) leads to airway inflammation and remodelling. However, the direct effect of gaseo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lin, JinHeng, Taggart, Michael, Borthwick, Lee, Fisher, Andrew, Brodlie, Malcolm, Sassano, M. Flori, Tarran, Robert, Gray, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100124/
https://ncbi.nlm.nih.gov/pubmed/33953304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89051-4
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