Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface

MEF2 and NKX2-5 transcription factors interact with each other in cardiogenesis and are necessary for normal heart formation. Despite evidence suggesting that these two transcription factors function synergistically and possibly through direct physical interactions, molecular mechanisms by which the...

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Udgivet i:J Mol Biol
Main Authors: Lei, Xiao, Zhao, Jun, Sagendorf, Jared M., Rajashekar, Niroop, Xu, Jiang, Machado, Ana Carolina Dantas, Sen, Chandani, Rohs, Remo, Feng, Pinghui, Chen, Lin
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099449/
https://ncbi.nlm.nih.gov/pubmed/32681840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.07.004
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