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Impact of study design and statistical model in pharmacogenetic studies with gene‐treatment interaction

Gene‐treatment interactions, just like drug‐drug interactions, can have dramatic effects on a patient response and therefore influence the clinician decision at the patient’s bedside. Crossover designs, although they are known to decrease the number of subjects in drug‐interaction studies, are seldo...

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Pubblicato in:CPT Pharmacometrics Syst Pharmacol
Autori principali: Couffignal, Camille, Mentré, France, Bertrand, Julie
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099447/
https://ncbi.nlm.nih.gov/pubmed/33951752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12624
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