Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological roles. We found that IL-27 induces more sustained STA...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wilmes, Stephan, Jeffrey, Polly-Anne, Martinez-Fabregas, Jonathan, Hafer, Maximillian, Fyfe, Paul K, Pohler, Elizabeth, Gaggero, Silvia, López-García, Martín, Lythe, Grant, Taylor, Charles, Guerrier, Thomas, Launay, David, Mitra, Suman, Piehler, Jacob, Molina-París, Carmen, Moraga, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099432/
https://ncbi.nlm.nih.gov/pubmed/33871355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66014
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