Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and enhanced apoptosis at the gastrulation stage and then induced embryonic leth...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Dinh, Tra Thi Huong, Iseki, Hiroyoshi, Mizuno, Seiya, Iijima-Mizuno, Saori, Tanimoto, Yoko, Daitoku, Yoko, Kato, Kanako, Hamada, Yuko, Hasan, Ammar Shaker Hamed, Suzuki, Hayate, Murata, Kazuya, Muratani, Masafumi, Ema, Masatsugu, Kim, Jun-Dal, Ishida, Junji, Fukamizu, Akiyoshi, Kato, Mitsuyasu, Takahashi, Satoru, Yagami, Ken-ichi, Wilson, Valerie, Arkell, Ruth M, Sugiyama, Fumihiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2021
Konular:
Developmental Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099427/
https://ncbi.nlm.nih.gov/pubmed/33949947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50346
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