Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and enhanced apoptosis at the gastrulation stage and then induced embryonic leth...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Dinh, Tra Thi Huong, Iseki, Hiroyoshi, Mizuno, Seiya, Iijima-Mizuno, Saori, Tanimoto, Yoko, Daitoku, Yoko, Kato, Kanako, Hamada, Yuko, Hasan, Ammar Shaker Hamed, Suzuki, Hayate, Murata, Kazuya, Muratani, Masafumi, Ema, Masatsugu, Kim, Jun-Dal, Ishida, Junji, Fukamizu, Akiyoshi, Kato, Mitsuyasu, Takahashi, Satoru, Yagami, Ken-ichi, Wilson, Valerie, Arkell, Ruth M, Sugiyama, Fumihiro
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099427/
https://ncbi.nlm.nih.gov/pubmed/33949947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50346
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