IL‐19 induced by IL‐13/IL‐17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP‐9 expression via ERK/NF‐κB signaling pathway

BACKGROUND: Tissue remodeling is a crucial characteristic of chronic rhinosinusitis (CRS). Imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is crucial for the pathologic tissue remodeling in CRS. Elevation of interleukin (IL)‐19 or MMP‐9 levels i...

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Vydáno v:Clin Transl Allergy
Hlavní autoři: Li, Xia, Huang, Jiancong, Chen, Xiaohong, Lai, Xiaoping, Huang, Zizhen, Li, Yue, Li, Shuaixiang, Chang, Lihong, Zhang, Gehua
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099262/
https://ncbi.nlm.nih.gov/pubmed/33900049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/clt2.12003
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