SMARCAD1-mediated active replication fork stability maintains genome integrity

The stalled fork protection pathway mediated by breast cancer 1/2 (BRCA1/2) proteins is critical for replication fork stability. However, it is unclear whether additional mechanisms are required to maintain replication fork stability. We describe a hitherto unknown mechanism, by which the SWI/SNF-re...

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Udgivet i:Sci Adv
Main Authors: Lo, Calvin Shun Yu, van Toorn, Marvin, Gaggioli, Vincent, Paes Dias, Mariana, Zhu, Yifan, Manolika, Eleni Maria, Zhao, Wei, van der Does, Marit, Mukherjee, Chirantani, G. S. C. Souto Gonçalves, João, van Royen, Martin E., French, Pim J., Demmers, Jeroen, Smal, Ihor, Lans, Hannes, Wheeler, David, Jonkers, Jos, Chaudhuri, Arnab Ray, Marteijn, Jurgen A., Taneja, Nitika
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099181/
https://ncbi.nlm.nih.gov/pubmed/33952518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe7804
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