A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated

Multiple candidate vaccines to prevent COVID-19 have entered large-scale phase 3 placebo-controlled randomized clinical trials, and several have demonstrated substantial short-term efficacy. At some point after demonstration of substantial efficacy, placebo recipients should be offered the efficacio...

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Veröffentlicht in:Ann Intern Med
Hauptverfasser: Follmann, Dean, Fintzi, Jonathan, Fay, Michael P., Janes, Holly E., Baden, Lindsey R., El Sahly, Hana M., Fleming, Thomas R., Mehrotra, Devan V., Carpp, Lindsay N., Juraska, Michal, Benkeser, David, Donnell, Deborah, Fong, Youyi, Han, Shu, Hirsch, Ian, Huang, Ying, Huang, Yunda, Hyrien, Ollivier, Luedtke, Alex, Carone, Marco, Nason, Martha, Vandebosch, An, Zhou, Honghong, Cho, Iksung, Gabriel, Erin, Kublin, James G., Cohen, Myron S., Corey, Lawrence, Gilbert, Peter B., Neuzil, Kathleen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American College of Physicians 2021
Schlagworte:
Research and Reporting Methods
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099035/
https://ncbi.nlm.nih.gov/pubmed/33844575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7326/M20-8149
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