Assessing Durability of Vaccine Effect Following Blinded Crossover in COVID-19 Vaccine Efficacy Trials

BACKGROUND: Several candidate vaccines to prevent COVID-19 disease have entered large-scale phase 3 placebo-controlled randomized clinical trials and some have demonstrated substantial short-term efficacy. Efficacious vaccines should, at some point, be offered to placebo participants, which will occ...

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Veröffentlicht in:medRxiv
Hauptverfasser: Follmann, Dean, Fintzi, Jonathan, Fay, Michael P., Janes, Holly E., Baden, Lindsey, Sahly, Hana El, Fleming, Thomas R., Mehrotra, Devan V., Carpp, Lindsay N., Juraska, Michal, Benkeser, David, Donnell, Deborah, Fong, Youyi, Han, Shu, Hirsch, Ian, Huang, Ying, Huang, Yunda, Hyrien, Ollivier, Luedtke, Alex, Carone, Marco, Nason, Martha, Vandebosch, An, Zhou, Honghong, Cho, Iksung, Gabriel, Erin, Kublin, James G., Cohen, Myron S., Corey, Lawrence, Gilbert, Peter B., Neuzil, Kathleen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745130/
https://ncbi.nlm.nih.gov/pubmed/33336213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.14.20248137
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