Assessing Durability of Vaccine Effect Following Blinded Crossover in COVID-19 Vaccine Efficacy Trials

BACKGROUND: Several candidate vaccines to prevent COVID-19 disease have entered large-scale phase 3 placebo-controlled randomized clinical trials and some have demonstrated substantial short-term efficacy. Efficacious vaccines should, at some point, be offered to placebo participants, which will occ...

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Publicado no:medRxiv
Main Authors: Follmann, Dean, Fintzi, Jonathan, Fay, Michael P., Janes, Holly E., Baden, Lindsey, Sahly, Hana El, Fleming, Thomas R., Mehrotra, Devan V., Carpp, Lindsay N., Juraska, Michal, Benkeser, David, Donnell, Deborah, Fong, Youyi, Han, Shu, Hirsch, Ian, Huang, Ying, Huang, Yunda, Hyrien, Ollivier, Luedtke, Alex, Carone, Marco, Nason, Martha, Vandebosch, An, Zhou, Honghong, Cho, Iksung, Gabriel, Erin, Kublin, James G., Cohen, Myron S., Corey, Lawrence, Gilbert, Peter B., Neuzil, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745130/
https://ncbi.nlm.nih.gov/pubmed/33336213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.14.20248137
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