A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated

Multiple candidate vaccines to prevent COVID-19 have entered large-scale phase 3 placebo-controlled randomized clinical trials, and several have demonstrated substantial short-term efficacy. At some point after demonstration of substantial efficacy, placebo recipients should be offered the efficacio...

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Publicado en:Ann Intern Med
Main Authors: Follmann, Dean, Fintzi, Jonathan, Fay, Michael P., Janes, Holly E., Baden, Lindsey R., El Sahly, Hana M., Fleming, Thomas R., Mehrotra, Devan V., Carpp, Lindsay N., Juraska, Michal, Benkeser, David, Donnell, Deborah, Fong, Youyi, Han, Shu, Hirsch, Ian, Huang, Ying, Huang, Yunda, Hyrien, Ollivier, Luedtke, Alex, Carone, Marco, Nason, Martha, Vandebosch, An, Zhou, Honghong, Cho, Iksung, Gabriel, Erin, Kublin, James G., Cohen, Myron S., Corey, Lawrence, Gilbert, Peter B., Neuzil, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado: American College of Physicians 2021
Assuntos:
Research and Reporting Methods
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099035/
https://ncbi.nlm.nih.gov/pubmed/33844575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7326/M20-8149
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