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The use of consensus sequence information to engineer stability and activity in proteins

The goal of protein design is to create proteins that are stable, soluble, and active. Here we focus on one approach to protein design in which sequence information is used to create a “consensus” sequence. Such consensus sequences comprise the most common residue at each position in a multiple sequ...

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Vydáno v:Methods Enzymol
Hlavní autoři: Sternke, Matt, Tripp, Katherine W., Barrick, Doug
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098710/
https://ncbi.nlm.nih.gov/pubmed/32896279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2020.06.001
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