Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL

Lymph node (LN) is a key tissue in the pathophysiology of mature blood cancers, especially for chronic lymphocytic leukemia (CLL). Within the multiple de-regulated pathways affecting CLL homeostasis, the CC-chemokine receptor 7 (CCR7) grants homing of CLL cells into the LN where protective environme...

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Veröffentlicht in:MAbs
Hauptverfasser: Cuesta-Mateos, Carlos, Juárez-Sánchez, Raquel, Mateu-Albero, Tamara, Loscertales, Javier, Mol, Wim, Terrón, Fernando, Muñoz-Calleja, Cecilia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2021
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Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098074/
https://ncbi.nlm.nih.gov/pubmed/33944659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2021.1917484
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