Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

Anti–programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to patients with advanced melanoma. The composition of the gut microbiota correlates with anti–PD-1 efficacy in preclinical models and cancer patients. To investigate whether resistance to anti–PD-1 can be overc...

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Publicado en:Science
Autores principales: Davar, Diwakar, Dzutsev, Amiran K., McCulloch, John A., Rodrigues, Richard R., Chauvin, Joe-Marc, Morrison, Robert M., Deblasio, Richelle N., Menna, Carmine, Ding, Quanquan, Pagliano, Ornella, Zidi, Bochra, Zhang, Shuowen, Badger, Jonathan H., Vetizou, Marie, Cole, Alicia M., Fernandes, Miriam R., Prescott, Stephanie, Costa, Raquel G. F., Balaji, Ascharya K., Morgun, Andrey, Vujkovic-Cvijin, Ivan, Wang, Hong, Borhani, Amir A., Schwartz, Marc B., Dubner, Howard M., Ernst, Scarlett J., Rose, Amy, Najjar, Yana G., Belkaid, Yasmine, Kirkwood, John M., Trinchieri, Giorgio, Zarour, Hassane M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097968/
https://ncbi.nlm.nih.gov/pubmed/33542131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abf3363
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