Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

Anti–programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to patients with advanced melanoma. The composition of the gut microbiota correlates with anti–PD-1 efficacy in preclinical models and cancer patients. To investigate whether resistance to anti–PD-1 can be overc...

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Publicat a:Science
Autors principals: Davar, Diwakar, Dzutsev, Amiran K., McCulloch, John A., Rodrigues, Richard R., Chauvin, Joe-Marc, Morrison, Robert M., Deblasio, Richelle N., Menna, Carmine, Ding, Quanquan, Pagliano, Ornella, Zidi, Bochra, Zhang, Shuowen, Badger, Jonathan H., Vetizou, Marie, Cole, Alicia M., Fernandes, Miriam R., Prescott, Stephanie, Costa, Raquel G. F., Balaji, Ascharya K., Morgun, Andrey, Vujkovic-Cvijin, Ivan, Wang, Hong, Borhani, Amir A., Schwartz, Marc B., Dubner, Howard M., Ernst, Scarlett J., Rose, Amy, Najjar, Yana G., Belkaid, Yasmine, Kirkwood, John M., Trinchieri, Giorgio, Zarour, Hassane M.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097968/
https://ncbi.nlm.nih.gov/pubmed/33542131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abf3363
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