Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

Anti–programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to patients with advanced melanoma. The composition of the gut microbiota correlates with anti–PD-1 efficacy in preclinical models and cancer patients. To investigate whether resistance to anti–PD-1 can be overc...

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Udgivet i:Science
Main Authors: Davar, Diwakar, Dzutsev, Amiran K., McCulloch, John A., Rodrigues, Richard R., Chauvin, Joe-Marc, Morrison, Robert M., Deblasio, Richelle N., Menna, Carmine, Ding, Quanquan, Pagliano, Ornella, Zidi, Bochra, Zhang, Shuowen, Badger, Jonathan H., Vetizou, Marie, Cole, Alicia M., Fernandes, Miriam R., Prescott, Stephanie, Costa, Raquel G. F., Balaji, Ascharya K., Morgun, Andrey, Vujkovic-Cvijin, Ivan, Wang, Hong, Borhani, Amir A., Schwartz, Marc B., Dubner, Howard M., Ernst, Scarlett J., Rose, Amy, Najjar, Yana G., Belkaid, Yasmine, Kirkwood, John M., Trinchieri, Giorgio, Zarour, Hassane M.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097968/
https://ncbi.nlm.nih.gov/pubmed/33542131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abf3363
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