Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis

BACKGROUND: Several studies demonstrate that endoplasmic reticulum (ER) stress-mediated epithelial-mesenchymal transition (EMT) is involved in the process of bleomycin (BLM)-induced pulmonary fibrosis. Tauroursodeoxycholic acid (TUDCA), a bile acid with chaperone properties, is an inhibitor of ER st...

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Pubblicato in:BMC Pulm Med
Autori principali: Tong, Bin, Fu, Lin, Hu, Biao, Zhang, Zhi-Cheng, Tan, Zhu-Xia, Li, Se-Ruo, Chen, Yuan-Hua, Zhang, Cheng, Wang, Hua, Xu, De-Xiang, Zhao, Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097922/
https://ncbi.nlm.nih.gov/pubmed/33952237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-021-01514-6
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